Clinico-pathological analysis of 6 cases of post-transplant lymphoproliferative disorders.
- Author:
Zhao-ming WANG
1
;
Shu-sen ZHENG
;
Wei DING
;
Li-jun WANG
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Female; Follow-Up Studies; Humans; Lymphoproliferative Disorders; etiology; pathology; Male; Middle Aged; Postoperative Complications; pathology; Prognosis; Transplantation, Homologous; pathology
- From: Chinese Journal of Hematology 2007;28(8):514-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate clinical and pathological features of post-transplant lymphoproliferative disorders (PTLD) and its significance in diagnosis.
METHODSSix cases of PTLD were studied by light microscope, immunohistochemistry, in-situ hybridization, and gene rearrangement analysis. The clinical and follow-up information were also reviewed.
RESULTSAmong the 6 cases, 3 with monomorphic PTLD were renal transplant recipients, and died 4, 2, and 1 months after diagnosis. 2 were liver transplant recipients, 1 of whom with monomorphic PTLD died 5 months after diagnosis, the other one was diagnosed as early lesion of PTLD and the post-bone marrow transplant case was classified as polymorphic PTLD who survived for 12 months after diagnosis of PTLD. EBER 1/2 DNA was demonstrated in 4 cases.
CONCLUSIONSPTLD is a lymphoproliferative disease with distinctive morphologic and clinical characteristics after organ transplantation. The prognosis of PTLD correlates with the pathological subtypes and clinical stage.