Analysis of overexpression of vascular endothelial growth factor-C in patients with angioimmunoblastic T-cell lymphoma.
- Author:
Wei-li ZHAO
1
;
Yan-Yan LIU
;
François PLASSA
;
Xiao-Long JIN
;
Li WANG
;
Anne JANIN
;
Zhi-Xiang SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Immunoblastic Lymphadenopathy; metabolism; pathology; Lymphoma, T-Cell; metabolism; pathology; Male; Middle Aged; Neovascularization, Pathologic; Vascular Endothelial Growth Factor C; metabolism
- From: Chinese Journal of Hematology 2007;28(10):664-666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the vascular endothelial growth factor-C (VEGF-C) expression and its clinical significance in malignant lymphoma.
METHODSLymphoma cells were isolated by laser microdissection. VEGF-C expression in lymphoma tissue and microdissected lymphoma cells was measured by realtime quantitative PCR. Meanwhile, vessel ultrastructure was identified by transmission electron microscopy.
RESULTSComparing with that in 8 patients with reactive lymphocyte hyperplasia, VEGF-C was overexpressed in angioimmunoblastic T-cell lymphoma, both in lymphoma tissue (n = 18, P = 0.0020) and in microdissected lymphoma cells (n = 10, P < 0.0001). Increased VEGF-C level was associated with bone marrow infiltration (P = 0.0039), skin involvement (P = 0.0046) and high-risk international prognostic index (P = 0.0302). In VEGF-C overexpressed cases, ultrastructural study showed dystrophic vessels, with swelling endothelial cells and absence of pericytes.
CONCLUSIONThe value of VEGF-C expression might be a biomarker of disease progression in angioimmunoblastic T-cell lymphoma.
