Analysis of prognostic factors in 74 cases of diffuse large B-cell lymphoma.
- Author:
Jing WANG
1
;
Xiao-Yan KE
;
Ling-Zhi ZHAO
;
Min LI
;
Hong-Mei JING
;
Ji-Jun WANG
;
Wei ZHAO
;
Zi-fen GAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Female; Follow-Up Studies; Humans; Immunohistochemistry; Lymphoma, Large B-Cell, Diffuse; diagnosis; metabolism; pathology; therapy; Male; Middle Aged; Prognosis; Survival Analysis
- From: Chinese Journal of Hematology 2007;28(10):667-670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship of clinic features, lab findings, the origin of tumor cell as well as prognosis in Chinese patients with diffuse large B-cell lymphoma( DLBCL).
METHODSSeventy four cases of primarily diagnosed DLBCL were analyzed. Immunohistochemistry stain was used to check the expressions of Bcl-6,CD10 and MUM1.
RESULTSAmong the 74 patients, the average age was 58.5 years, the ratio of male to female was 1.64:1. 23.2% (16/69) cases developed in lymph node, 15.9% (11/ 69) in the extra node area. Among 55 follow-up cases, 13 (23.6%) died, and 12 (92.3%) died in the first year after diagnosis. The prognosis analysis showed that diagnosed at age > 65 years (P = 0.036), and the international prognostic index (IPI) (P = 0.009) were independent prognostic factors; origin of tumor cell had a trend to be a prognostic factor, but no statistic difference (P = 0.086). beta2-MG and Bcl-6 expression had no relation with the prognosis.
CONCLUSIONThe middle and old-aged male patients are the most common in DLBCL and the first-year mortality rate is higher. The age at diagnosis and IPI can predict the clinical outcome. The origin of tumor cell might suggest the prognosis.
