Determination of ADAMTS13 antigen and activity levels in patients with acute myocardial infarction and acute ischemic stroke.

Author: Ning-Zheng DONG ¹ ; Fang LIU ; Shun-Dong JI ; Chang-Geng RUAN
Author Information

1. iangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Publication Type:Journal Article
MeSH: ADAM Proteins; blood; ADAMTS13 Protein; Aged; Aged, 80 and over; Brain Infarction; blood; Female; Humans; Male; Middle Aged; Myocardial Infarction; blood; von Willebrand Factor; metabolism
From: Chinese Journal of Hematology 2008;29(3):161-163
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the ADAMTS13 antigen levels and activity in patients with acute myocardial infarction (AMI) and acute ischemic stroke (AIS), and explore its significance in these diseases.
METHODSADAMTS13 activity levels were detected by a new developed Frests-vWF73 kit, ADAMTS13 antigen levels by ELISA kit, and vWF multimers by electrophoresis.
RESULTSADAMTS13 antigen in normal control, AMI and AIS was (878 +/- 198), (618 +/- 188) and (702 +/- 155) U/L, and ADAMTS13 activity was (81.7 +/- 13.9)%, (59.2 +/- 22.1 )% and (65.4 +/- 15.8)%, respectively, being significantly decreased in AMI and AIS patients.
CONCLUSIONADMATS13 might involve in arterial infarction diseases.