Study of fibrinolysis inhibitors in 117 acute leukemia patients.
- Author:
Wen WANG
1
;
Chun-Yan JI
;
Jing-Jing YE
;
Yuan-Yuan ZHU
;
Dong-Mei GUO
;
Min JI
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Adult; Aged; Carboxypeptidase B2; blood; Child; Female; Humans; Leukemia; blood; Male; Middle Aged; Plasminogen Activator Inhibitor 1; blood; Young Adult
- From: Chinese Journal of Hematology 2008;29(3):183-186
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical significance of fibrinolysis inhibitors including thrombin activatable fibrinolysis inhibitor(TAFI), plasminogen activator inhibitor (PAI) and alpha2-plasmin inhibitor (alpha2-PI) in acute leukemia (AL).
METHODSPAI-1 antigen and TAFI antigen were investigated by enzyme-linked immunosorbent assay and PAI activity, alpha2-PI activity, TAFI activity by chromatography substrate assay in 117 AL patients and 50 normal controls.
RESULTS1) alpha2-PI activities in AL patients were reduced, especially in ALL patients [(96.8 +/- 21.2)%]; 2) PAI-1 antigens in AML patients [(37.8 +/- 9.2) microg/L] were significantly higher than that in normal controls [(33.8 +/- 4.9) microg/L]; 3) PAI-1 antigens in APL [(37.8 +/- 9.0) microg/L] and AML-M5 patients [(39.9 +/- 11.6) microg/L] were higher and TAFI activities in APL patients [(13.3 +/- 4.8) mg/L] were lower than that in normal controls [(16.9 +/- 2.6) mg/L]; 4) PAI-1 antigens of relapsed/refractory patients (39.6 +/- 11.6) microg/L) were significantly elevated; 5) TAFI activities in bleeding patients [(13.2 +/- 5.3) mg/L] were significantly lower than that in normal control as well as non-bleeding patients (17.0 +/- 4.6) mg/L); 6) The severity of bleeding was negatively correlated with TAFI activity (r = - 0.276, P <0.05).
CONCLUSIONSHyperfibrinolysis caused partially by decrease of alpha2-PI and TAFI activity takes part in the pathogenesis of bleeding in AL.