Serum levels of IL-5 and LTB4 in children with Henoch-Schonlein purpura.
- Author:
Pei-Yuan LIAO
1
;
Sheng-Hua WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; C-Reactive Protein; analysis; Child; Child, Preschool; Female; Humans; Interleukin-5; blood; Leukotriene B4; blood; Male; Purpura, Schoenlein-Henoch; blood; etiology
- From: Chinese Journal of Contemporary Pediatrics 2006;8(3):198-200
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study investigated the serum levels of interleukin-5 (IL-5), leukotriene B4 (LTB4) and C-reactive protein (CRP) in children with Henoch-Schonlein purpura (HSP) at different phases to explore the role of IL-5, LTB4 and CRP in the pathogenesis of HSP.
METHODSSerum levels of IL-5, LTB4 and CRP in 27 normal children and 31 children with HSP at the acute phase and the early recovery phase were detected using ELISA.
RESULTSThe serum levels of IL-5, LTB4 and CRP in children with HSP were 53.8 +/- 4.2 pg/mL, 95.3 +/- 12.0 pg/mL and 36.10 +/- 11.78 mg/L, respectively at the acute phase. The values were significantly decreased at the early recovery phase (37.8 +/- 3.9 pg/mL, 45.7 +/- 10.1 pg/mL, 18.35 +/- 6.43 mg/L; P < 0.01), but remained higher than those in normal controls (12.7 +/- 3.2 pg/mL, 17.6 +/- 5.7 pg/mL, 4.75 +/- 2.85 mg/L; P < 0.01). The serum levels of IL-5 and LTB4 positively correlated to the CRP level.
CONCLUSIONSThe serum levels of IL-5 and LTB4 in children with HSP increased during the acute phase and decreased at the early recovery phase, suggesting that IL-5 and LTB4 may be involved in the pathogenesis of HSP.