Liver lesions in children with hepatitis B virus associated glomerulonephritis.
- Author:
Xi-Qiang DANG
1
;
Zhu-Wen YI
;
Xiao-Jie HE
;
Shuang-Hong MO
;
Zi-Chuan XU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Female; Glomerulonephritis; pathology; Hepatitis B; complications; pathology; Hepatitis B Core Antigens; analysis; Humans; Kidney; pathology; Liver; pathology; Male
- From: Chinese Journal of Contemporary Pediatrics 2006;8(4):275-278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the pathological changes of liver in children with hepatitis B virus associated glomerulonephritis (HBV-GN).
METHODSThirteen children with HBV-GN (aged from 2-14 years) underwent renal and liver biopsy. The biopsy findings were analyzed.
RESULTSDifferent degrees of hepatic lesions were seen in all of the 13 patients, mild lesions accounting for 69.2% (9/13). HBSAg positive was the most common in the liver tissue [76.9% (10/13)]. Among the renal lesions, membranous glomerulopathy accounted for 69.2%( 9/13), followed by membranoproliferative glomerulonephritis 30.8% (4/13). HBsAg and HBcAg positive were presented in all patients' kidney tissues. HBV antigens were detected in stroma between nephric tubule in all samples. Four patients presented with HBcAg positive in both live and kidneys.
CONCLUSIONSThe children with HBV-GN couple with liver lesions. The severity of the renal lesions is not always accord with that of the liver lesions. The appearance of HBcAg in both kidneys and liver indicates severe lesions of the two organs. It is suggested that a liver-kidney holistic treatment is necessary for children with HBV-GN.
