Variation and significance of serum and stool IL-18 and IFN-gamma levels in children with rotavirus enteritis.
- Author:
You-Gui GAO
1
;
Yu JIN
;
Yi-Ling LIU
;
Xin-Hua YE
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Enteritis; immunology; Feces; chemistry; Female; Humans; Infant; Interferon-gamma; blood; physiology; Interleukin-18; blood; physiology; Male; Rotavirus Infections; immunology
- From: Chinese Journal of Contemporary Pediatrics 2006;8(4):304-306
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the variation and significance of serum and stool IL-18 and IFN-gamma levels in children with rotavirus enteritis.
METHODSSerum and stool specimens from 50 children with acute rotavirus enteritis were collected before treatment. Serum and stool levels of IL-18 and IFN-gamma were measured using ELISA. Serum and stool specimens from 21 age and gender-matched healthy children were used as the Control group.
RESULTSSerum and stool levels of IL-18 and IFN-gamma in patients with rotavirus enteritis were significantly higher than those in the Control group. There was a negative correlation between the serum IFN-gamma level and the frequency of vomiting (r=-0.368, P < 0.05). The stool IL-18 level negatively correlated to the frequency of diarrhea (r=-0.414, P < 0.05). A positive correlation was found between the serum levels of IL-18 and IFN-gamma (r=0.416, P < 0.05).
CONCLUSIONSSerum and stool levels of IL-18 and IFN-gamma were increased and associated with the severity in children with rotavirus enteritis. IL-18 and IFN-gamma might have protective effects against acute rotavirus infection at the early stage.
