Protective effects of Jiashen Prescription () on myocardial infarction in rats.
- Author:
Ming-Jun ZHU
1
;
You-Ping WANG
;
Shi-Yang XIE
;
Wei-Hong LIU
;
Bin LI
;
Yong-Xia WANG
;
He WANG
;
Bo-Li ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Body Weight; Cardiotonic Agents; therapeutic use; Drugs, Chinese Herbal; therapeutic use; Heart Function Tests; Male; Myocardial Infarction; diagnostic imaging; drug therapy; pathology; physiopathology; Myocardium; pathology; Organ Size; Rats, Sprague-Dawley; Survival Analysis; Ultrasonography
- From: Chinese journal of integrative medicine 2015;21(6):417-422
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the effects of Jiashen Prescription (, JSP) on myocardial infarction (MI) size and cardiac function at the early stage of MI in rats.
METHODSOne hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle, JSP 3 and 6 g/(kg·d), or losartan 10 mg/(kg·d) for 1 week.
RESULTSCompared with the vehicle-treated MI rats, 6 g/(kg·d) JSP reduced MI size 3 days after MI (P<0.05), and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI (P<0.05). In addition, 6 g/(kg·d) JSP and losartan were equally effective in reducing MI size and enhancing cardiac functional recovery.
CONCLUSIONJSP reduces MI size and improves cardiac function after MI, suggesting that JSP has potential as a therapy for MI.
