A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection.
- Author:
Qun LU
1
;
Xi CHEN
;
Yang LI
;
Xiao-Hong ZHANG
;
Rong LIANG
;
Yong-Ping ZHAO
;
Li-Hui WEI
;
Huan SHEN
Author Information
1. Reproductive Medical Center, Peking University People's Hospital, Beijing 100044, China.
- Publication Type:Case Reports
- MeSH:
Adult;
Female;
Fertilization in Vitro;
methods;
Humans;
Live Birth;
Male;
Oocytes;
cytology;
Pregnancy;
Sperm Injections, Intracytoplasmic;
methods
- From:
Chinese Medical Journal
2012;125(3):546-548
- CountryChina
- Language:English
-
Abstract:
Total or near-total fertilization failure after intracytoplasmic sperm injection (ICSI) is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 (A23187) activation on one-day-old unfertilized oocytes in a patient whose husband suffered oligoasthenoteratozoospermia, and who had experienced repeated near-total fertilization failure after ICSI. In the second ICSI cycle, only one oocyte was fertilized while nine were unfertilized. Oocyte activation with A23187 were performed on the one-day-old unfertilized oocytes after ICSI and resulted in fertilization and embryo transfer. A clinical pregnancy was achieved and a healthy baby was born. To our knowledge, this is the first reported case of a healthy birth after oocyte activation on the one-day-old unfertilized oocyte. This indicates that "rescue oocyte activation" on one-day-old unfertilized oocytes after ICSI may be helpful for preventing total or near-total fertilization failure after ICSI.
