Expressions of key molecules affiliated cytoskeleton in laryngeal squamous cell carcinoma and their implications for prognosis
10.3760/cma.j.issn.1673-0860.2012.10.011
- VernacularTitle:细胞骨架分子与喉鳞状细胞癌患者复发及预后的关系
- Author:
Wei GAO
1
;
Bin-Quan WANG
;
Chun-Ming ZHANG
;
Shu-Xin WEN
;
Gang-Gang CHEN
;
Hui HUANGFU
;
Yan FENG
;
Sen ZHANG
Author Information
1. 山西医科大学附属第一医院
- Keywords:
Laryngeal neoplasms;
Carcinoma,squamous cell;
Carrier proteins;
Microfilament protein;
Cytoskeletal proteins;
Paxillin;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2012;47(10):841-847
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of key assemblies of cytoskeleton,Fascin-1,Ezrin and Paxillin,in laryngeal squamous cell carcinoma (LSCC) and their correlation with clinicopathologic characteristics,cancer recurrence and survival of patients with LSCC. Methods The expressions of Fascin-1,Ezrin and Paxillin proteins were detected by immunohistochemistry in 199 cases of LSCC.Unconditional Logistic regression model or Cox proportional hazards model was used for the analyses of recurrent risks and prognostic factors. Results Significantly increased expression of Fascin-1,Ezrin or Paxillin expression was showed in the LSCC with poorly differentiated,positively cervical lymph nodal metastasis,and clinical stage Ⅲ+ Ⅳ respectively ( P ＜ 0.05 ).The expressions of three kinds of proteins in the recurrent cases were higher than those in non-recurrent cases respectively ( x2 were 42.479,43.673 and 22.261,P ＜0.05).The highest recurrence rate(69.1％ ) was observed in group of cases with the highly co-expression of the three kinds of proteins( P ＜ 0.05 ).The expression of Fascin-1 ( OR =7.89,95％ CI 2.26 - 27.53,P =0.001 ),or Ezrin ( OR =2.51,95％ CI 1.18 - 5.32,P ＜ 0.001 ) was independent risk for recurrence.Five-year disease-free survival rates of patients with high expression of Fascin-1,Ezrin or Paxillin were lower than those of patients with negative or low expressions for the proteins ( P ＜ 0.05 ).Patients with highly co-expression of three kinds of proteins showed the poorest survival prognosis,with a 5-year disease free survival ( DFS ) of only 26.4％ ( P ＜ 0.05 ),and expressions of three proteins were independent prognostic factors for 5-year DFS ( P ＜ 0.05 ).Conclusion Fascin-1,Ezrin,and Paxillin were correlative with LSCC progression and might be potential predictors for cancer recurrence and survival of patients with LSCC,as well as therapeutic targets for LSCC.
