(1)H-MRS study of auditory cortex in patients with presbycusis.
- Author:
Xian-ming CHEN
1
;
Xiao-qing DOU
;
Yong-hui LIANG
;
Li-wei ZHANG
;
Bi-qiang LUO
;
Yi-hong DENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aspartic Acid; analogs & derivatives; metabolism; Auditory Cortex; metabolism; Case-Control Studies; Choline; metabolism; Creatine; metabolism; Female; Glutamic Acid; metabolism; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Presbycusis; metabolism; pathology; Young Adult; gamma-Aminobutyric Acid; metabolism
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(10):852-855
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the metabolic changes of auditory cortex in patients with presbycusis by using proton magnetic resonance spectroscopy ((1)H-MRS).
METHODSTen normal hearing volunteers (youth group), 10 normal hearing of elderly (aged group) and 8 patients with presbycusis (presbycusis group) were checked with proton magnetic resonance spectroscopy. N-acetylaspartic acid (NAA), creatine (Cr), choline (Cho), γ-aminobutyric acid (GABA), glutamic acid (Glu) compound were measured. The differences between the groups were semi-quantitatively analyzed.
RESULTSWhen compared with youth group, reduced NAA/Cr, increased Cho/Cr were found in the aged group and presbycusis group (P < 0.05). GABA/Cr ratio and Glu/Cr ratio were significant difference between presbycusis group and youth group (P < 0.05). There were no significant difference in the GABA/Cr and Glu/Cr ratios in the bilateral auditory cortex between the youth group and the aged group (P > 0.05). When compared with aged group, the metabolic changes of auditory cortex in patients with presbycusis were remarkable (P < 0.05).
CONCLUSIONS(1)H-MRS is a noninvasive technique that can provide useful information concerning the metabolic changes of auditory cortex in human. In comparison to the aged group and the youth group, the changes of NAA, GABA, Cho and Glu is found in auditory cortex in patients with presbycusis.
