Analysis of the level and significance of immunoglobulin free light chain in nasal secretion and in serum of patients with allergic rhinitis and non-allergic rhinitis
10.3760/cma.j.issn.1673-0860.2012.11.007
- VernacularTitle:免疫球蛋白游离轻链在变应性及非变应性鼻炎中的表达水平及意义探讨
- Author:
Cui-Da MENG
1
;
Zhen DONG
;
Ji-Chao SHA
;
Lin LI
;
Dong-Dong ZHU
Author Information
1. 吉林大学中日联谊医院耳鼻咽喉头颈外科
- Keywords:
Rhinitis,allergic,perennial;
Rhinitis,allergic,seasonal;
Rhinitis,non-allergic;
Immunoglobulin light chains;
Tryptase;
Eosinophil cationic protein
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2012;47(11):908-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the immunoglobulin free light chain (FLC) from nasal secretion and serum of patients with allergic rhinitis(AR) and non-allergic rhinitis(NAR) for the purpose of exploring the possible immunological mechanism.Methods Sixty consecutive patients were selected between September and December in 2009,involving 30 patients with AR and 30 patients with NAR diagnosed by symptoms,signs,skin prick tests (SPT) and specific IgE (sIgE).Thirty volunteers were chosen as healthy control (HC).According to the visual analogue scale (VAS) scores,the nasal symptoms of AR and NAR,including sneeze,nasal discharge,nasal obstruction and nasal itching were compared.ELISA was used to detect the total IgE,eosinophil cationic protein(ECP),mast cell tryptase(MCT),κFLC,λFLC in nasal secretion and serum.The data was analyzed by SPSS 17.0 software.Results There was no statistical difference between AR and NAR group in nasal symptoms (t value was 1.189,0.741,0.758,0.797,respectively,all P ＞ 0.5);In serum,κFLC,λFLC,ECP,MCT increased in NAR group compared to HC group (all P ＜ 0.05);λFLC increased in NAR group compared to AR group(P ＜ 0.05),κFLC,total IgE and ECP was increased in AR group compared to HC group.In nasal secretion,κFLC,λFLC,ECP and MCT increased in AR and NAR groups compared to HC group,and the ECP and total IgE were significantly increased in AR group compared to NAR group (all P ＜ 0.05).In nasal secretion,the FLC revealed a significantly higher correlation trend with MCT (r value was 0.518 and 0.484,all P ＜0.05),and in serum revealed a significant correlation trend with ECP (r value was 0.343 and 0.342,all P ＜ 0.05).Conclusion Immunoglobulin FLC takes part in the path of physiological process of AR and NAR with the immunological mechanism.
