CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population.
- Author:
Qing ZHOU
;
Pei-ran ZHU
;
Ming-chao ZHANG
;
Jing ZHANG
;
Wei-jun JIANG
;
Meng-xia NI
;
Shuai-mei LIU
;
Qiu-yue WU
;
Wei-wei LI
;
Hao-qin XU
;
Xin-yi XIA
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Case-Control Studies; China; Cytochrome P-450 CYP1A1; genetics; Gene Frequency; Genotype; Homozygote; Humans; Infertility, Male; genetics; Male; Middle Aged; Polymorphism, Genetic; Young Adult
- From: National Journal of Andrology 2016;22(5):420-424
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the correlation of the CYP1A1 (rs4646422) gene polymorphisms with male infertility in the Chinese Han population.
METHODSUsing the Mass ARRAY iPLEX GOLD technique, we conducted a case-control study on theCYPlA1 (rs4646422) gene polymorphisms in 636 infertile males aged 21-49 years (case group) and 442 normal healthy men aged 23-47 years (control group) of the Chinese Han population. We analyzed the genotypes and allele frequencies in the two groups ofsubjects with the SPSS 20.0 software.
RESULTSCompared with the wild homozygous genotype GG, the heterozygous genotype AG (OR = 1.06, 95% CI 0.81-1.38) and homozygous genotype AA (OR = 1.11, 95% CI 0.56-2.21) showed no correlation with male infertility, nor did the mutant allele A (OR = 1.06, 95% CI 0.85-1.32) in comparison with the wild allele G.
CONCLUSIONThe CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population.