Application value of real-time contrast-enhanced ultrasound in transrectal prostate biopsy.

Ming-kun Chen; Xiong-qiang Peng; Hong-mei Liu; Cun-dong Liu; Qing-zhu Wei; Lin Zhong; Jian-kun Yang; Qi-zhao Zhou; Kang-yi Xue; Wen-bin Guo; Jun Bian

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Application value of real-time contrast-enhanced ultrasound in transrectal prostate biopsy.

Author: Ming-Kun CHEN ¹ ; Xiong-Qiang PENG ² ; Hong-Mei LIU ² ; Cun-Dong LIU ¹ ; Qing-Zhu WEI ³ ; Lin ZHONG ³ ; Jian-Kun YANG ¹ ; Qi-Zhao ZHOU ¹ ; Kang-Yi XUE ¹ ; Wen-Bin GUO ¹ ; Jun BIAN ¹
Author Information

1. Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
2. Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
3. Department of Pathology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
Publication Type:Journal Article
Keywords: positivity rate; prostate cancer; real-time contrast-enhanced ultrasound; transrectal ultrasonoraphy; prostate biopsy
MeSH: Contrast Media; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Humans; Magnetic Resonance Imaging; Male; Prospective Studies; Prostate; diagnostic imaging; pathology; Prostate-Specific Antigen; blood; Prostatic Neoplasms; blood; diagnostic imaging; pathology; Ultrasonography, Interventional
From: National Journal of Andrology 2016;22(8):698-703
CountryChina
Language:Chinese
Abstract:
ObjectiveTo explore the application value of real-time contrast-enhanced ultrasound (RTCEU) in improving the detection rate of transrectal ultrasound-guided prostate biopsy.
METHODSThis prospective study included 91 male patients with abnormally high PSA (4－20 μg/L) or abnormalities in DRE or MRI, who underwent 12+X prostate biopsy following conventional transrectal ultrasonography (TRUS) and RTCEU examination. We compared the numbers of suspected prostatic nodules before and after RTCEU as well as the detection rates of prostate cancer between conventional TRUS-guided 12PBx and 12PBx plus lesion-targeted biopsy procedures.
RESULTSTotally, 57 of the 86 suspected lesions on TRUS (66.3%), and 108 of the 118 abnormal nodules on RTCEU (91.5%) were confirmed to be prostate cancer. RTCEU achieved a significantly higher detection rate than TRUS (P<0.01). A total of 39 cases of prostate cancer (42.8%) were detected by RTCEU, while only 28 (30.7%) by TRUS, with statistically significant difference in the detection rate between the two procedures (P=0.033).
CONCLUSIONSReal-time contrast-enhanced ultrasound can significantly improve the detection rate of prostate cancer and provide a valuable guide to targeted prostate biopsy.