Ubiquitin-proteasome system and sperm DNA repair: An update.
- Author:
Guo-Wei ZHANG
1
;
Hong-Cai CAI
1
;
Xue-Jun SHANG
1
Author Information
1. Department of Andrology, Jinling Hospital Affiliated to Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- Keywords:
ubiquitin-proteasome system;
damage repair;
male infertility;
sperm DNA
- MeSH:
Cell Cycle Proteins;
physiology;
DNA Damage;
DNA Repair;
physiology;
Humans;
Male;
Proteasome Endopeptidase Complex;
physiology;
Signal Transduction;
physiology;
Spermatogenesis;
physiology;
Spermatozoa;
Ubiquitin;
physiology;
Ubiquitin-Conjugating Enzymes;
physiology;
Ubiquitin-Protein Ligases;
physiology;
Ubiquitination
- From:
National Journal of Andrology
2016;22(9):834-837
- CountryChina
- Language:Chinese
-
Abstract:
The ubiquitin-proteasome system (UPS) is a proteasome system widely present in the human body, which is composed of ubiquitin (Ub), ubiquitin activating enzymes (E1), ubiquitin conjugating enzymes (E2), ubiquitin protein ligases (E3), 26S proteasome, and deubiquitinating enzymes (DUBs) and involved in cell cycle regulation, immune response, signal transduction, DNA repair as well as protein degradation. Sperm DNA is vulnerable to interference or damage in the progression of chromosome association and homologous recombination. Recent studies show that UPS participates in DNA repair in spermatogenesis by modulating DNA repair enzymes via ubiquitination, assisting in the identification of DNA damage sites, raising damage repair-related proteins, initiating the DNA repair pathway, maintaining chromosome stability, and ensuring the normal process of spermatogenesis.
