Relaxation mechanism of smooth muscle cells and its relationship with penile erection.
- Author:
Hu ZHAO
1
;
Rui JIANG
1
Author Information
1. Department of Urology, The First Hospital Affiliated to Southwest Medical University, Luzhou, Sichuan 646000, China.
- Publication Type:Journal Article
- Keywords:
P2Y receptor;
calcium activated potassium channel;
erectile dysfunction;
perivascular tissue;
relaxation;
estrogen receptor;
smooth muscle cell;
sulfur dioxide
- MeSH:
Carbon Monoxide;
physiology;
Erectile Dysfunction;
etiology;
physiopathology;
Humans;
Hydrogen Sulfide;
metabolism;
Male;
Muscle Contraction;
Muscle, Smooth;
Myocytes, Smooth Muscle;
physiology;
Nitric Oxide;
physiology;
Penile Erection;
physiology;
Potassium Channels, Calcium-Activated;
physiology;
Receptors, Estrogen;
physiology;
Receptors, Purinergic P2Y;
physiology;
Sulfur Dioxide;
metabolism
- From:
National Journal of Andrology
2016;22(9):838-842
- CountryChina
- Language:Chinese
-
Abstract:
The contractile and diastolic function of smooth muscle cells (SMCs) is closely related to penile erection and erectile dysfunction (ED). In addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), sulfur dioxide (SO2), estrogen receptor (ER), P2Y receptor, perivascular tissue (PVT), and calcium activated potassium channel (Kca) are found to be involved in the relaxation of SMCs. This review updates the mechanisms of the relaxation of SMCs and its relationship with ED.
