Autophagy and phenotypic modulation of corpus cavernosum smooth muscle cells in hypoxia-induced erectile dysfunction.
- Author:
Ji-Kun DENG
1
;
Yan TAN
1
Author Information
1. Department of Andrology, Renmin Hospital, Hubei Medical college, Shiyan, Hubei 442000, China.
- Publication Type:Journal Article
- Keywords:
autophagy;
corpus cavernosum smooth muscle cell;
hypoxia;
phenotypic modulation
- From:
National Journal of Andrology
2016;22(11):1025-1029
- CountryChina
- Language:Chinese
-
Abstract:
The correlation between hypoxia and erectile dysfunction (ED) has been universally acknowledged for decades in the academic world. The phenotypic modulation of corpus cavernosum smooth muscle cells (CCSMCs) is regarded as one of the factors of hypoxia-induced ED, but the underlying mechanisms remain unclear. Recent researches show some correlation between autophagy and phenotypic modulation of CCSMCs, which may be associated with the overexpressions of PDGF, TGF-β, and vasoactive factors in the organism following hypoxia.
