Endophytic fungi from Ginkgo biloba and their biological activities.
- Author:
Hongsheng YU
1
;
Lei ZHANG
;
Lin LI
;
Wenchao LI
;
Ting HAN
;
Liangdong GUO
;
Luping QIN
Author Information
- Publication Type:Journal Article
- MeSH: Antifungal Agents; pharmacology; Aspergillus fumigatus; drug effects; Candida albicans; drug effects; Cryptococcus neoformans; drug effects; Fluconazole; pharmacology; Fungi; chemistry; drug effects; isolation & purification; Ginkgo biloba; microbiology; Microbial Sensitivity Tests; Trichophyton; drug effects
- From: China Journal of Chinese Materia Medica 2010;35(16):2133-2137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the isolation method, identification and screen for bioactivities endophytic fungi from ginkgo.
METHODEndophytic fungi from ginkgo were separated. By means of microdilution method, activities of endophytes against pathogenic fungi were tested. Then, using DPPH, the antioxidant activities were measured.
RESULTNine strains (16.1%) showed antifungal activities against Candida albicans, Cryptococcus neoformans, Trichophyton rubrum and Aspergillus fumigatus. Among these bioactive strains, the growth of T. rubrum was strongly inhibited by T-1-2-1, as the MIC80 was equal to fluconazole, the positive control. Five strains (8.9%) showed antioxidant activities. Among them sample T-3-2-2 and T-6-5-7 showed the strongest antioxidant activities.
CONCLUSIONEndophytic fungi of ginkgo would be potential and rich resources for drug development.
