Preparation and pharmacodynamic evaluation of diammonium glycyrrhizinate-loaded chitosan nanoparticles.
- Author:
Yunfeng ZHU
1
;
Qingri CAO
;
Shilin YANG
;
Jinghao CUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chitosan; chemistry; Colitis, Ulcerative; chemically induced; drug therapy; Dextran Sulfate; toxicity; Disease Models, Animal; Female; Glycyrrhizic Acid; chemistry; therapeutic use; Male; Mice; Nanoparticles; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(16):2138-2141
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare the diammonium glycyrrhizinate-loaded chitosan nanoparticles (DG-CS NPs), and evaluate its pharmaceutical properties and pharmacodynamic effects on ulcerative colitis (UC).
METHODDG-CS NPs were prepared by spray drying method and optimized by orthogonal design. The morphology, size and in vitro release of DG-CS NPs were investigated. The therapeutic effects of DG-CS NPs on UC mice induced by dextran sulfate were evaluated preliminarily through disease active index method.
RESULTThe size of DG-CS NPs with loading capacity about (51.25 +/- 1.75)% was in the range of 300-600 nm. The release of DG-CS NPs was associated with environmental pH value and displayed significant therapeutic and preventive effects on UC.
CONCLUSIONDG-CS NPs prepared by spray drying method showed efficacy on UC mice.
