Preparation of sustained release microspheres containing extracts from Caulis sinomenii with polylactic acid and their release property in vitro.

Wen Zhan; Xingxiang Zhang

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Preparation of sustained release microspheres containing extracts from Caulis sinomenii with polylactic acid and their release property in vitro.

Author: Wen ZHAN ¹ ; Xingxiang ZHANG
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1. Institute of Functional Fibers, Tianjin Municipal Key Laboratory of Fiber Modification and Functional Fibers, Tianjin Polytechnic University, Tianjin 300160, China.
Publication Type:Journal Article
MeSH: Drugs, Chinese Herbal; administration & dosage; chemistry; Lactic Acid; chemistry; Microspheres; Polyesters; Polymers; chemistry; Sinomenium; chemistry
From: China Journal of Chinese Materia Medica 2010;35(16):2142-2145
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo prepare polylactic acid microspheres containing total alkaloid extracts of Caulis sinomenii and study their release characteristics in vitro.
METHODPolylactic acid microspheres containing total alkaloid extracts of C. sinomenii were prepared by O/W emulsification solvent-evaporation process. The microspheres were characterized in terms of morphology, encapsulation efficiency, and particle size distribution. The effect of different conditions on release property of microspheres was studied.
RESULTThe formed microspheres were spherical with smooth surfaces. The encapsulation efficiency and rate of drug loading were (83.4 +/- 5.63)% and (8.7-0.35)%, respectively. The distribution of particle size was uniform and the average size was (21.5 +/- 1.22) microm. In vitro release study revealed that the 32-hour accumulative release percentage reached 80%.
CONCLUSIONPolylactic acid microspheres containing total alkaloid extracts of C. sinomenii were prepared successfully. Microspheres with good sustained-release characteristics can be produced by controlling different process parameters.