Preparation of multivariant-phospholipid complex of Ginkgo biloba extract.
- Author:
Zhipeng CHEN
1
;
Jun SUN
;
Dan LIU
;
Yanyu XIAO
;
Baochang CAI
Author Information
- Publication Type:Journal Article
- MeSH: Ginkgo biloba; chemistry; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Phospholipids; chemistry; Water; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(16):2146-2150
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare Ginkgo biloba extract multivariant-phospholipid complex(MGBP) and improve the vitro dissolution of ginkgo total flavonoids by adding another water-soluble carrier in phospholipid complex.
METHODMGBP was prepared using solvent evaporation method with Poloxamer-188 as the carrier and the multivariant complex was analyzed by DSC and X-diffraction technique. The physicochemical properties of the MGBP we also studied, including apparent oil-water distribution coefficients in different pH aqueous solution and its release in vitro.
RESULTThe in vitro dissolution of ginkgo total flavonoids was significantly increased while the apparent oil-water distribution coefficient was improved after been made into multivariant-phospholipid complex.
CONCLUSIONThe preparation technology of MGBP is simple and economic. MGBP can significantly increase the vitro dissolution of ginkgo total flavonoids and improve oil-water distribution coefficients, which can be the reference for the bioavailability in vivo in the further researches.
