Optimization of extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction by uniform design.
- Author:
Fang LI
1
;
Zhaowang ZHANG
;
Xiumei SUN
;
Weifeng WANG
;
Meifang MA
Author Information
- Publication Type:Journal Article
- MeSH: Drugs, Chinese Herbal; chemistry; Hydrogen-Ion Concentration
- From: China Journal of Chinese Materia Medica 2010;35(16):2151-2156
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction.
METHODThe best extraction condition of the semi-bionic extraction for Guizhi Fuling pill decoction was optimized by uniform design was optimized with paeoniflorin, cinnamic acid, laetrile, pachymic acid, total polysaccharose and dry extract as the indexes.
RESULTThe optimized extraction condition is that extracting for 3 times with solvent pH values of 4.98, 7.35 and 8.00, respectively, and the total extracting time was 4.99 h.
CONCLUSIONIn consideration of manufacturing fact, the pH value of thrice extractions is set at 5.0, 7.5, 8.0 respectively, and the extracting time is 2.0, 1.5, 1.5 h in turn.
