Experimental study on antitumor effects of extracts from Actinidia argutaor.
- Author:
Lan WANG
1
;
Chen KANG
;
Weipeng YANG
;
Manling LI
;
Yanli WANG
;
Yiwei WANG
;
Luqi HANG
;
Rixin LIANG
;
Qing YANG
;
Xiaojie YIN
Author Information
- Publication Type:Journal Article
- MeSH: Actinidia; chemistry; Animals; Antineoplastic Agents, Phytogenic; chemistry; pharmacology; therapeutic use; Cell Cycle; drug effects; Cell Line, Tumor; Drugs, Chinese Herbal; chemistry; pharmacology; therapeutic use; Male; Mice; Mice, Inbred ICR
- From: China Journal of Chinese Materia Medica 2010;35(16):2184-2186
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the inhibitory effect of extract from Actinidia argutaor on in vivo and in vitro carcinomata, and explore its mechanism.
METHODThe in vivo S180 and H22 model were used to observe the effect of A. argutaor on inhibitory rate of carcinomata, organ relative weight of spleen and thymus gland and the release of tumor necrosis factor. A549 cells were exposed to extract from A. argutaor with different concentrations for 24, 48, 72 hours. MTT assay was used to evaluate the inhibiting effects of extract from A. argutaor on the proliferation of the cells. Flow cytometry was applied to detect cell cycle.
RESULTThe inhibitory effects of the extracts on in vivo and in vitro carcinomata were observed, the inhibitory rate for S180 and H22 line was 33.32% and 34.62% respectively. The extracts could inhibit the proliferation of A549 cells during G0-G1 period and significantly decrease the cell ratio of S stage.
CONCLUSIONThe extracts from A. argutaor showed a good antineoplastic activity.
