Role of reticulated platelets and platelet-associated antibody in differential diagnosis of idiopathic thrombocytopenic purpura.
- Author:
Yan LIU
1
;
Zhen WANG
;
Bai-Xiang YUAN
;
Xiao-Yan WANG
;
Qiong WU
;
Hong YUAN
Author Information
1. Department of Clinical Laboratory Examination, Dalian Medical University, Dalian, Liaoning Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Blood Platelets;
immunology;
Case-Control Studies;
Diagnosis, Differential;
Female;
Humans;
Immunoglobulin G;
blood;
Male;
Middle Aged;
Platelet Count;
Purpura, Thrombocytopenic, Idiopathic;
blood;
diagnosis;
Young Adult
- From:
Journal of Experimental Hematology
2011;19(4):979-982
- CountryChina
- Language:Chinese
-
Abstract:
The objective of this study was to evaluate the role of reticulated platelets (RF) and platelet-associated antibody (PAIg) in differential diagnosis of idiopathic thrombocytopenic purpura (ITP). The immature platelet fraction (IPF) of 34 ITP patients, 36 non-ITP patients and 411 normal people were detected by Sysmex XE-5000 automated blood cell analyser and PAIgG content was detected by enzyme-linked immunosorbent assay. All results were analysed statistically. The results showed that IPF of ITP patients was significantly higher than that of non-ITP patients and normal people respectively (p < 0.05). For diagnosis of ITP, IPF positive rate of ITP patients was significantly higher than that of non-ITP patients (p < 0.05). There was no significant difference between the positive rate of PAIgG in ITP and non-ITP patients (p > 0.05). The sensibility, specificity and negative predictive value of IPF were higher than those of PAIgG, while the positive predictive value of IPF was a little lower than that of PAIgG. The area under receiver operating characteristic curve of IPF was larger than that of PAIgG. It is concluded that both IPF and PAIgG detection are valuable in differential diagnosis of ITP. The diagnostic value of IPF is better than that of PAIgG.
