Advance of studies on microRNA and myelodysplastic syndrome.
- Author:
Yu-Juan YANG
1
;
Xiao LI
Author Information
1. Department of Hematology, Shanghai Jiaotong University Sixth People Hospital, Shanghai 200233, China.
- Publication Type:Journal Article
- MeSH:
Hematopoiesis;
Humans;
MicroRNAs;
Myelodysplastic Syndromes;
genetics;
pathology
- From:
Journal of Experimental Hematology
2011;19(4):1079-1082
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA), evolutionarily conserved, endogenous, small, noncoding RNA molecule of about 22 nucleotides in length, have been recently attributed a crucial role in numerous physiological and pathological processes including the regulation of cellular development, differentiation, proliferation, apoptosis and oncogenesis. Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic disorders characterized clinically and morphologically by ineffective hematopoiesis and increased risk of leukaemic transformation. The role of miRNA abnormal expression in pathogenesis and prognosis of MDS is reviewed in this article, including miRNA related with pathogenesis, miRNA related with prognosis of MDS and so on.
