Production of the specific monovalent pertussis serum fast in the Institute of Vaccine
- Author:
Bon Phan
- Publication Type:Journal Article
- Keywords:
vaccine
- MeSH:
vaccines;
Whooping Cough
- From:Journal of Practical Medicine
2002;435(11):46-48
- CountryViet Nam
- Language:Vietnamese
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Abstract:
Species were applied by the Centre for the vaccine quality control including Bordetella pertussis GL 353 type 1; Bordetella pertussis 360 E type1, 2; Bordetella pertussis H36 type 1, 3. The methods: preparation of the medium Bordet- Gengou; production of the serum fast according to the methods of the surface culture in Bordet-Gengo medium in bottle of Roux; immunization and collection of serum fast; absorption of the non- specific antibody. The results have shown that the antibody effect of type 1, type 1, 2 and type 3, 4 in the 14th day after the 6 injection of the outlines immuned higher than this in the seventh day. The combination of pertussis antigen with Aluminum phosphate increases immunoability in all three types with some effects. Therefore, a monovalent pertussis serum fast has made in the allowed standard. The ability of agglutination and specificity of the produced pertussis serum fast were the same as these of the England National Institute of vaccine and biological substances
