Bortezomib combined with autologous peripheral blood hematopoietic stem cell transplantation for therapy of patients with multiple myeloma.
- Author:
Qian ZHANG
1
;
Hai BAI
;
Cun-Bang WANG
;
Mei-Liang WANG
;
Ya-Qin LING
;
Bing WU
Author Information
1. Department of Hematology, Lanzhou General Hospital, Lanzhou Military Area, Lanzhou, Gansu Province, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Boronic Acids;
therapeutic use;
Bortezomib;
Combined Modality Therapy;
Humans;
Male;
Middle Aged;
Multiple Myeloma;
therapy;
Peripheral Blood Stem Cell Transplantation;
Pyrazines;
therapeutic use;
Transplantation Conditioning;
methods
- From:
Journal of Experimental Hematology
2011;19(5):1234-1236
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to evaluate the therapeutic efficacy of bortezomib combined with autologous peripheral blood hematopoietic stem cell transplantation (autoPBSCT) for patients with multiple myeloma (MM). 5 patients underwent autologous hematopoietic stem cell transplantation. Bortezomib treatment was supplied for patients before autoPBSCT and in the conditioning of transplantation, it was also used in maintaining treatment. Patients with transplantation adopted bortezomib plus melphalan conditioning regimen. The number of infused MNC and number of CD34(+) cells were 4.06×10(8) (4.09×10(8) - 4.37×10(8))/kg and 3.98×10(6) (2.49×10(6) - 8.2×10(6))/kg respectively. The results showed that hematopoiesis was reconstituted in 5 patients, with a neutrophil cell count more than 0.5×10(9)/L at day 14 (13 - 25 days) after transplantation and platelet count more than 50×10(9)/L at day 28 (21 - 41 days) after transplantation. Transplantation-associated death was not observed. 5 patients were disease-free survival. In conclusion, treatment of bortezomib combined with autologous peripheral hematopoietic stem cell transplantation is an effective method for patients with multiple myeloma. Use of bortezomib after transplantation might still be favourable to MM patients, for survival prolongation and life quality improvement.
