Influence of HLA-G on immunoregulatory function of human amniotic mesenchymal cells.
- Author:
Jia-Ping WANG
1
;
Gui-Fang OUYANG
Author Information
1. Department of Hematology, Medical College of Ningbo University, Ningbo, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Amnion;
cytology;
HLA-G Antigens;
immunology;
Humans;
Immune Tolerance;
Mesenchymal Stromal Cells;
cytology;
immunology
- From:
Journal of Experimental Hematology
2011;19(5):1325-1328
- CountryChina
- Language:Chinese
-
Abstract:
Human leukocyte antigen G (HLA-G), a kind of non-classical major histocompatibility complex class I antigens, can inhibit inflammatory reaction, assist tumor cells to escape from immune surveillance and promote the immunologic tolerance of the graft. HLA-G, expressed and secreted by human amniotic mesenchymal cells (HAMC), suppresses the functions of NK cells, T cells and B cells and modulates the activity of dendritic cells (DC). These findings provide a theoretical basis for illustrating the mechanism of immunosuppression on HAMC. In this article, the recent advances on not only the gene and the molecular structure of HLA-G, but also the possible mechanisms of HLA-G in immunoregulatory function of HAMC, as well as the relation of HLA-G with HAMC, NK, DC, T and B cells are reviewed.
