Estrogen Receptor alpha, beta and Progesteron Receptor Expression in Gynecomastia Using Immunohistochemical Staining.
- Author:
Sun Cheol PARK
1
;
Kee Hwan KIM
;
Chang Hyeok AHN
;
Jeong Soo KIM
;
Hae Myung JEON
;
Eun Jung LEE
;
Sang Seol JUNG
Author Information
1. Department of Surgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, Uijongbu, Korea.
- Publication Type:Original Article
- Keywords:
Gynecomastia;
Estrogen receptor alpha;
beta;
Progesteron receptor
- MeSH:
Male;
Humans
- From:Journal of the Korean Surgical Society
2001;60(3):268-272
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Gynecomastia is a common male breast abnormality and primarily occurs in puberty and senescence. The obvious etiological role of hormonal changes in gynecomastia, plus the discovery of estrogen receptor in normal and neoplastic breast, has spurred several investigations of ER content in male gynecomastic tissues. The results have been inconsistent and the fraction of ER-positive specimens has varied from 0~90%. METHODS: Immunohistochemical hormonal receptor analysis using monoclonal estrogen receptor (ER) alpha, beta and progesteron receptor (PR) was performed on the breast tissues of 58 patients with gynecomastia between January 1995 and January 2000 in the Department of Surgery, Uijongbu St. Mary's Hospital. These results were statistically compared with clinical data. RESULTS: 48 cases (82.8%) were ERalpha positive and 55 cases (94.8%) were ERbeta positive and PR positivity was noted in 55 cases (94.8%). There was negative relationship between ERalpha and age, PR and location. CONCLUSION: This study demonstrates that intracellular steroid receptors are present in most gynecomastic tissues. Additionally, it supports the general assumption that estrogen and progesteron may be two of the hormones responsible for the development of gynecomastia.
