Correlation between typing of peripheral neuroblastic tumors and prognosis: a clinicopathologic study of 135 cases.
- Author:
Min-zhi YIN
1
;
Zhong-de ZHANG
;
Jing MA
;
Ping SHEN
;
Jie-feng CHEN
;
Hui-zhen ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Female; Follow-Up Studies; Ganglioneuroblastoma; pathology; surgery; Ganglioneuroma; pathology; surgery; Humans; Infant; Infant, Newborn; Male; Neoplasm Staging; Neuroblastoma; classification; pathology; surgery; Peripheral Nervous System Neoplasms; classification; pathology; surgery; Retrospective Studies; Survival Rate
- From: Chinese Journal of Pathology 2011;40(3):151-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic characteristics of peripheral neuroblastic tumors and to investigate the prognostic significance of International Neuroblastoma Pathology Classification (INPC).
METHODSOne hundred and thirty-five cases of peripheral neuroblastic tumors encountered in Shanghai Children's Medical Center were enrolled into the study. All the cases were classified according to INPC and International Neuroblastoma Staging System (INSS). The follow-up data were analyzed.
RESULTSThe consensus diagnoses of the 135 cases were as follows: 80 cases (59.2%) of neuroblastoma, 24 cases (17.8%) of ganglioneuroblastoma, intermixed, 17 cases (12.6%) of ganglioneuroma and 14 cases (10.4%) of ganglioneuroblastoma, nodular. The cases were subdivided into 2 subgroups: favorable histology (number = 90, 66.7%) and unfavorable histology (number = 45, 33.3%). According to INSS, the number of cases in stages I, II, III and IV was 22 (16.3%), 24 (17.8%), 34 (25.2%) and 55 (40.7%), respectively. The survival of peripheral neuroblastic tumors correlated with histologic diagnosis, INPC and INSS (P < 0.05).
CONCLUSIONDiagnostic categorization of peripheral neuroblastic tumors according to INPC is of prognostic value.
