Clinicopathologic and immunohistochemical study of 23 cases of mesenchymal chondrosarcoma.
- Author:
Zong-guo PANG
1
;
Xing-zhuang HE
;
Lan-yan WU
;
Wei WEI
;
Xiao-yu LIU
;
Dian-ying LIAO
;
Feng-yuan LI
;
Xian-liang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: 12E7 Antigen; Adolescent; Adult; Antigens, CD; metabolism; Bone Neoplasms; diagnostic imaging; metabolism; pathology; surgery; Cell Adhesion Molecules; metabolism; Child; Chondrosarcoma, Mesenchymal; diagnostic imaging; metabolism; pathology; secondary; surgery; Female; Follow-Up Studies; Humans; Immunohistochemistry; Lung Neoplasms; secondary; Male; Mediastinal Neoplasms; diagnostic imaging; metabolism; pathology; surgery; Middle Aged; Neoplasm Recurrence, Local; Orbital Neoplasms; diagnostic imaging; metabolism; pathology; surgery; Radiography; SOX9 Transcription Factor; metabolism; Vimentin; metabolism; Young Adult
- From: Chinese Journal of Pathology 2011;40(6):368-372
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic and immunohistochemical features of mesenchymal chondrosarcoma.
METHODSThe clinical and histologic features of 23 cases of mesenchymal chondrosarcoma were analyzed. Immunohistochemical study was also performed in 14 of the cases.
RESULTSThe age of patients ranged from 12 to 47 years. Fourteen of them occurred in males. Thirteen cases involved the bony skeleton and 5 cases affected the soft tissue. The patients presented with pain and/or swelling. Histologically, the tumor consisted of a mixture of undifferentiated small round cells and hyaline cartilage. Transition between the two components was demonstrated and growth plate-like cartilage was observed. Immunohistochemical study showed that the small round cells were positive for Sox9 (14/14), CD99 (12/14), vimentin (6/14), CD56 (4/14), CD57 (4/14), neuron-specific enolase (3/14) and desmin(1/14). They were negative for Coll-II, S-100 protein, epithelial membrane antigen, pan-cytokeratin, synaptophysin, chromogranin A, CD34 and c-erbB2.
CONCLUSIONSMesenchymal chondrosarcoma is a rare malignant tumor. Thorough histologic examination, when coupled with immunohistochemical findings, is helpful in arriving at a correct diagnosis.
