Study on Helicobacter infection in liver tissue from hepatocellular carcinoma.
- Author:
Ning LI
1
;
Shu-hui ZHANG
;
Shi-ying XUAN
;
Xin QIANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; microbiology; Case-Control Studies; Helicobacter Infections; complications; Helicobacter hepaticus; genetics; isolation & purification; Humans; In Situ Hybridization; Liver; microbiology; Liver Neoplasms; microbiology
- From: Chinese Journal of Epidemiology 2006;27(10):894-896
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between Helicobacter species and hepatocellular carcinoma(HCC).
METHODSLiver samples resected during operation from 34 patients with HCC diagnosed by histopathology and 20 without primary liver carcinoma as controls were studied. The two groups of sample were cranked out pathologic slice for in situ hybridization of Helicobacter, Helicobacter pylori and Helicobacter hepaticus. Qualitative and quantitative studies were used to assess the correlation of liver tissue Helicobacter infection with HCC.
RESULTS64.71% (22/34). of the samples of HCC showed positive for Helicobacter specific 16S rRNA-mRNA gene by in situ hybridization, while none was positive in controls (P < 0.01).
CONCLUSIONHelicobacter pylori were found in the liver of patients with HCC.
