Recognizing the vaccination strategy of pertussis according to the family aggregation feature of transmission.

Yarong LI; Xiaoguai Liu; Lingxia Lei; Fangzhi HE; Ruina LI; Xiaokang Peng; Xiaofang Zhang; Ying Liu; Yanli XI; Heqing Huang; Zengguo Wang

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Recognizing the vaccination strategy of pertussis according to the family aggregation feature of transmission.

Author: Yarong LI ¹ ; Xiaoguai LIU ² ; Lingxia LEI ² ; Fangzhi HE ² ; Ruina LI ² ; Xiaokang PENG ² ; Xiaofang ZHANG ² ; Ying LIU ³ ; Yanli XI ³ ; Heqing HUANG ³ ; Zengguo WANG ⁴
Author Information

1. No. 3 Department of Infectious Diseases, Xi'an Children Hospital, Xi'an 710002, China. Email: lyr640101@163.com.
2. No. 3 Department of Infectious Diseases, Xi'an Children Hospital, Xi'an 710002, China.
3. Xi'an Center for Disease Control and Prevention.
4. Xi'an Center for Disease Control and Prevention. Email: william_wzg@126.com.
Publication Type:Journal Article
MeSH: Adult; Age Distribution; Child; Child, Preschool; Delayed Diagnosis; Diagnostic Errors; Family; Humans; Infant; Whooping Cough; epidemiology; transmission
From:Chinese Journal of Epidemiology 2014;35(8):953-955
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo understand the age distribution of pertussis patients admitted in the children hospital and to analyze the source of infection as well as its transmission patterns.
METHODSPatients visiting to the Children Hospital and epidemiologically related cases during Feb. 2012 to Aug. 2013 were tested to confirm the diagnosis. Excel 2007 software was used to analyze the age distribution and clinical symptoms of clinic cases, the source of infection or subsequent cases.
RESULTS165 out of 254 clinically suspicious pertussis cases and 38 out of the 54 epidemiologically related cases were confirmed of having pertussis infection. There were 138 (83.6%) cases under 1 year of age in the confirmed clinical cases and 36 (94.7%) cases older than 20 years of age among the confirmed epidemiologically related pertussis cases. All the confirmed epidemiologically related cases were misdiagnosed or missed for diagnosis. As the source of pertussis infection in confirmed clinical cases, parents played an imported role among 25 of the 32 cases. Transmission from infants and/or little children to adults were also observed in this study.
CONCLUSIONInfants accounted for the most among the pertussis patients that visiting the clinics. Adults, being misdiagnosed or missed diagnosed, were the main sources of infection to infants. Epidemics of pertussis occurred under family aggregation. Further study was in need to develop the proper strategy for pertussis booster vaccination.