Impact of isolated diastolic hypertension on new-onset cardiovascular and cerebro-vascular diseases
10.3760/cma.j.issn.0254-6450.2014.08.018
- VernacularTitle:单纯舒张期高血压对新发心脑血管事件的影响
- Keywords:
Cardio-cerebral vascular events;
Isolated diastolic hypertension;
Cohort study
- From:
Chinese Journal of Epidemiology
2014;35(8):956-960
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of isolated diastolic hypertension (IDH) on new-onset cardio-cerebral vascular diseases (CVD).Methods This cohort study involved 101 510 participants who were employees of the Kailuan Group-a state-run coal mining company,in 2006 and 2007.Among them,6 780 subjects were diagnosed with IDH,35 448 subjects were diagnosed with high-normal blood pressure and 19 460 subjects were diagnosed with normal tension.However,none of them had the history of either cardio-cerebral vascular disease or malignant cancer.Cardio-cerebral vascular events including cerebral infarction,cerebral hemorrhage,acute myocardial infarction were recorded every 6 months during the follow-up (47.1 ± 4.8)period.Multivariable Cox proportional hazards regression models were used to analyze the risk factors of first-ever CVD events.Results 1) There were 675 CVD events occurred during the follow-up period.The incidence rates of CVD events (1.7％ vs.0.9％),cerebral infarction (1.0％ vs.0.6％) and cerebral hemorrhage (0.4％ vs.0.1％) were significantly higher in IDH group than that in the normal tension group (all P＜0.05).2) After adjustment for other established CVD risk factors,the hazards ratios became 1.67 (95％ CI:1.28-2.17) for total CVD events and 1.59 (95％ CI:1.12-2.27) for cerebral infarction and 2.67 (95％CI:1.54-4.65) for cerebral hemorrhage in the IDH group.3) In stratified analysis on age,after adjustment for other established CVD risk factors,the hazards ratio was 2.22 (95％ CI:1.41-3.50) for cerebral infarction in lower 60 years old group,while the it was 7.27 (95％ CI:2.58-20.42) for cerebral hemorrhage in groups older than 60 years of age.Conclusion IDH was the independent risk factor for the total cardio-cerebral vascular events,on both cerebral infarction and cerebral hemorrhage.The predicted values of IDH for different CVD events were diverse on different age groups.
