Long term outcome of atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation
10.3760/cma.j.issn.0253-3758.2013.05.007
- VernacularTitle:携带KCNA5和NPPA基因突变的心房颤动患者三例的导管消融随访研究
- Keywords:
Atrial fibrillation;
Genes;
Mutation;
Catheter ablation
- From:
Chinese Journal of Cardiology
2013;41(5):387-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective The outcome of atrial fibrillation patients with genetic mutations post ablation was not well evaluated.Methods and Results Three atrial fibrillation patients with evidence of mutations in KCNA5 and NPPA post successful circumferential pulmonary vein ablation were included.Mutation in KCNA5 was found in one male patient with paroxysmal atrial fibrillation.He was free of atrial fibrillation post ablation after 46 months follow-up.Mutations in NPPA were found in two male patients with persistent atrial fibrillation and they were free from atrial fibrillation after 64 months and 38 months follow-up post circumferential pulmonary vein ablation,roof line and mitral isthmus line ablation.Conclusion Satisfactory long term results are observed in atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation.
