Effects of policosanol combined with simvastatin on serum lipids and sex hormones in male patients with hyperlipidemia
10.3760/cma.j.issn.0253-3758.2013.06.011
- VernacularTitle:多廿烷醇联合辛伐他汀对男性高脂血症患者血脂及性激素水平的影响
- Author:
Min TANG
1
;
Sai-Zhu WU
;
Xun GONG
Author Information
1. 南方医科大学南方医院心内科
- Keywords:
Hyperlipidemia;
Antilipemic agents;
Gonadal steroid hormones
- From:
Chinese Journal of Cardiology
2013;41(6):488-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects and safety of policosanol combined with simvastatin on serum lipids and sex hormones in male patients with hyperlipidemia.Methods This randomized,singleblinded,placebo-controlled study included 120 male patients with hyperlipidemia.Patients were devided randomly into treatment group(n =60) and control group (n =60).Patients in the treatment group were administrated with simvastatin (40 mg/d) plus policosanol (20 mg/d),and those in the control group were treated with simvastatin (40 mg/d) plus placebo (20 mg/d).The values of total cholesterol (TC),triglyceride(TG),high density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol(LDL-C),testosterone(T) and estradiol(E2) were assessed before and after 16 weeks treatment.Drug-induced adverse effects were observed.Results Baseline characteristics were similar between groups.TC,TG,LDL-C were(5.74 ± 0.99),(1.62 ± 0.69),(3.60 ± 0.56) mmol/L in the treatment group at baseline and significantly reduced after 16 weeks treatment (4.57 ± 0.58),(1.54 ± 0.55),(2.68 ± 0.38) mmol/L (all P ＜0.05).TC,LDL-C were(5.99 ± 0.93),(3.76 ± 0.42) mmol/L in the control group at baseline and significantly reduced after 16 weeks treatment(5.03 ± 0.59),(2.98 ± 0.28)mmol/L (all P ＜ 0.05) while TG remained unchanged post 16 weeks therapy in the control group.Simvastatin plus policosanol achieved a significantly greater reduction in LDL-C and TC than simvastatin plus placebo (P ＜ 0.05).HDL-C,T and E2 were similar before and after 16 weeks treatments in both groups(P ＞ 0.05).The adverse reactions were similar between the two groups,most of them were mild and happened at the beginning of drug therapy and could be well tolerated.Conclusion Simvastatin/policosanol produces greater decreases in TC,LDL-C than simvastatin/placebo without resulting more side effects and changes on sex hormones.
