OBJECTIVETo systematically investigate the possible associations between G1165C and A145G polymorphism of β1-adrenoceptor (ADRB1) and resting heart rate (HRrest) in Northern Han Chinese.

METHODSHRrest of 700 healthy Northern Han Chinese were measured in the sitting position.SNPs were genotyped by the TaqMan assay.Genotypes were differentiated by analyzing the fluorescence levels of PCR products using an ABI Prism 7900HT Sequence Detector.

RESULTSHRrest was significantly lower in A145G AA carriers than in AG and GG carriers (all P < 0.01) . Multiple linear regression analysis showed that age, smoking habits, systolic blood pressure, triglyceride, serum creatinine and A145G polymorphism were associated with HRrest (P < 0.01) . A145G was significantly related with HRrest independent of other possible confounding variables, and the partial regression coefficient was 2.148 (P < 0.05) . After adjusting for other confounding factors, significant association between A145G and HRrest was only found in male subjects (P < 0.05) but not in female subjects (P > 0.05) .

CONCLUSIONThe A145G polymorphism of ADRB1 gene is associated with HRrest in Northern male Han Chinese.