Coronary atherosclerosis lesion features in coronary artery disease patients complicating with metabolic syndrome
10.3760/cma.j.issn.0253-3758.2013.11.009
- VernacularTitle:冠心病合并代谢综合征患者冠状动脉粥样硬化的特性
- Author:
Yang GAO
1
;
Bin L(U)
;
Zhi-Hui HOU
;
Hui-Li CAO
;
Fang-Fang YU
;
Shi-Liang JIANG
;
Ru-Ping DAI
Author Information
1. 100037,国家心血管病中心中国医学科学院北京协和医学院阜外心血管病医院放射科心血管疾病国家重点实验室
- Keywords:
Coronary atherosclerosis;
Metabolic syndrome;
Coronary angiography
- From:
Chinese Journal of Cardiology
2013;41(11):935-939
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To compare coronary plaque burden,composition,distribution and the degree of coronary artery stenosis in invasive coronary angiography (ICA) diagnosed coronary artery disease (CAD)patients with or without metabolic syndrome (MetS).Methods From January 2008 to June 2011,consecutive patients underwent both coronary computed tomography angiography (CCTA) and ICA within three months were enrolled.Patients with history of previous percutaneous coronary interventions (PCI) and coronary artery bypass grafting (CABG) were excluded.Plaque characteristics and maximal luminal diameter stenosis were analyzed on a 16-segment basis as suggested by the American Heart Association classification.Results The study population consisted of 872 patients [age (60.2 ± 10.0) years,72.70％ males] including 377 patients with MetS and 495 patients without MetS.The median coronary artery calcium score (CACS) was higher in MetS patients than in non-MetS patients [102(10,410) vs.58(0,274),P ＜ 0.01].Percentage of patients with no coronary artery calcium was significantly lower in MetS group than in non-MetS group [19.63％ (74/377) vs.30.71％ (152/495),P ＜ 0.01],while percentage of patients with severe coronary calcium (CACS ≥ 1000) were significantly higher in MetS than non-MetS group [8.22％ (31/377) vs.4.65％ (23/495),P =0.03].The proportion of patients with 1-vessel disease was lower [23.61％ (89/377) vs.36.77％ (182/495),P ＜ 0.01],2-vessel [29.71 ％ (112/377) vs.22.83 ％ (113/ 495),P ＜ 0.05] and 3-vessel disease [35.54％ (134/377) vs.24.44％ (121/495),P ＜ 0.01] were higher in MetS group than in non-NetS group.Calcified plaque of LM and the middle and distal coronary artery were significantly higher in MetS group than in non-MetS group(all P ＜ 0.05).Conclusions CAD patients with MetS are associated with severer coronary artery calcium deposition and higher percentage of calcified plaque in the middle and distal coronary arteries and severer obstructive coronary vessels.
