Clinical and experimental study of two cases of myelodysplastic syndrome with t(3; 5) (q25; q34) translocation.
- Author:
Yafang WU
1
;
Yongquan XUE
;
Meng ZHAO
;
Saijuan CHEN
;
Jinlan PAN
;
Dingwei LU
Author Information
- Publication Type:Case Reports
- MeSH: Adolescent; Adult; Antigens, CD; analysis; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 5; Humans; In Situ Hybridization, Fluorescence; methods; Leukocytes, Mononuclear; classification; immunology; Male; Myelodysplastic Syndromes; genetics; physiopathology; Translocation, Genetic
- From: Chinese Journal of Hematology 2002;23(6):304-306
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo report two myelodysplatic syndromes (MDS) patients with t(3; 5) (q25; q34).
METHODSChromosome specimens were prepared by short-term culture of bone marrow cells. Karyotype analysis was performed by R banding technique, chromosome painting (fluorescence in situ hybridization, FISH) by using whole chromosome 3 and 5 probes in case 1.
RESULTSThe clinical and hematological findings were compatible with diagnosis of MDS. Karyotype analysis showed that both patients had identical t(3; 5) (q25; q34) translocation. A reciprocal translocation between chromosomes 3q and 5q was proved by FISH in one patient.
CONCLUSIONSt(3; 5) translocation is a rare chromosome abnormality specifically associated with MDS and frequently displays trilineage dysplasia. Chromosome painting technique is a reliable tool for detecting this translocation.
