Allogeneic bone marrow transplantation for the treatment of Bruton disease.
- Author:
Xiaojun HUANG
1
;
Hongxia SHI
;
Nailan GUO
;
Daopei LU
Author Information
- Publication Type:Case Reports
- MeSH: Agammaglobulinemia; blood; therapy; Bone Marrow Transplantation; Child; Child, Preschool; Hemoglobins; metabolism; Humans; Immunoglobulins; blood; Leukocyte Count; Male; Transplantation, Homologous; Treatment Outcome
- From: Chinese Journal of Hematology 2002;23(10):528-530
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the efficacy of allogeneic bone marrow transplantation (allo-BMT) for the treatment of Bruton disease.
METHODSHLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice.
RESULTSRecovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively. Serum immunoglobin rose gradually to normal level in three months. Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively. There was no serious graft-versus-host-disease.
CONCLUSIONStem cell transplantation is a choice for the treatment of Bruton disease.
