Exploration of acute graft versus host disease and its risk factors after allo-hematopoietic stem cell transplantation.
- Author:
Yu-hong CHEN
1
;
Xiao-jun HUANG
;
Nai-lan GUO
;
Han-yun REN
;
Yao-chen ZHANG
;
Lan-ping XU
;
Zhi-yong GAO
;
Dao-pei LU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Adult; Child; Child, Preschool; China; epidemiology; Female; Graft vs Host Disease; epidemiology; etiology; pathology; Hematopoietic Stem Cell Transplantation; adverse effects; Humans; Incidence; Male; Middle Aged; Prognosis; Risk Factors; Severity of Illness Index; Survival Analysis; Time Factors; Transplantation, Homologous
- From: Chinese Journal of Hematology 2003;24(2):61-63
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the incidence, prognosis and risk factors of the acute graft versus host disease (aGVHD) after allo-hematopoietic stem cell transplantation (allo-HSCT).
METHODSThe clinical data of 118 cases undergone 120 times of allo-HSCT were analyzed.
RESULTaGVHD was observed in 63 cases (52.57%) including 17 severe cases (14.17%). The patients with aGVHD had a poor outcome, the 2-year overall survival rates were 61.40%, 64.08% and 17.65% for the non aGVHD, mild (degree I-II) and severe (degree III-IV) aGVHD groups respectively (P < 0.01). However, the relapse rates were 12.48%, 20.53% and 0% with no statistic significance. Unrelated transplantation and HLA-mismatch were the risk factors for aGVHD.
CONCLUSIONaGVHD is a common complication after allo-HSCT, the earlier it takes place, the poorer the prognosis.
