Study on the characteristics of patients with Creutzfeldt-Jakob disease under 2008 surveillance data in China
10.3760/cma.j.issn.0254-6450.2009.07.017
- VernacularTitle:中国2008年克雅氏病监测病例特征分析
- Author:
Chan TIAN
1
;
Chen GAO
;
Qi SHI
;
Jun HAN
;
Wei ZIIOU
;
Bao-Yun ZHANG
;
Yong-Jun GAO
;
Xiao-Ping DONG
Author Information
1. 中国疾病预防控制中心病毒病预防控制所
- Keywords:
Creutzfeldt-Jakob disease;
Surveillance;
14-3-3 protein;
PRNP gene
- From:
Chinese Journal of Epidemiology
2009;30(7):713-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the epidemiological and clinical characteristics of Creutzfeldt-Jakob disease (CJD) in China. Methods Clinical and epidemical data on patients from China CJD surveillance network was analyzed. Blood and cerebral spinal fluid (CSF) specimens from these patients were collected. Western blot assay was used to detect 14-3-3 protein in CSF, PCR and sequencing assay were used for analyzing the polymorphism of 129 amino acid and mutation of PRNP gene. Results A total number of 31 probable and 11 possible sporadic CJD patients were identified. Additionally, one patient with Gerstmann-Straussler-Scheinker syndrome (GSS) and 2 familial CJD cases were identified. No geographic- or occupational-related events were observed among these cases. The mean age of onset on the probable or possible CJD patients were 56.7 and 57.4 years old, with sex ratios of the probable CJD patients as 8:9 and the possible one as 5:6 respectively. Rapid progressive dementia was the main foremost symptom, presenting in 33.3% of the CJD patients. Probable CJD patients showed more clinical manifestations than those possible ones. Conclusion Geography distribution, occupation, ratio of gender and the mean onset age of the CJD eases in 2008 were consistent with the characteristics of the sporadic CJD.
