Retrospective cohort study on the rate of mother-to-child transmission among mothers infected with human immunodeficiency virus type 1 through blood transfusion
10.3760/cma.j.issn.0254-6450.2009.06.007
- VernacularTitle:输血感染艾滋病病毒1型母婴传播概率回顾性定群研究
- Author:
Su-Liang CHEN
1
;
Hong-Ru ZHAO
;
Xiao-Mei LI
;
Yu-Qi ZHANG
;
Guang-Sheng JIN
;
Cui-Ying ZHAO
;
Yan-Ping ZHANG
;
Guang-Yi BAI
;
Bao-Jun LI
;
Liang LIANG
;
Zhi-Qiang CHEN
;
Yan-Liang HUI
;
Fu-Bao LIU
;
Zhi-Xian XU
;
Jian-Guo ZHU
;
Yu-Rong MAO
Author Information
1. 河北省疾病预防控制中心
- Keywords:
Human immunodeficiency virus;
Mother-to-child transmission;
Probability;
Retrospective cohort study
- From:
Chinese Journal of Epidemiology
2009;30(6):564-566
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the rate of mother-to-child transmission (MTCT) on HIV-1. Methods All local residents from 8 townships in a region were screened for mothers who had a history of only one blood transfusion and 63 were found HIV-1 positive. A further study on these HIV-1 positive mothers and their children was conducted with the emphasis on the date of receiving blood transfusion, date and type of nationality, history regarding breastfeeding and so on. Sera specimens from 84 children born from 63 HIV-1 positive mothers were screened, using ELISA for HIV-1 antibody, and positive specimens were confirmed by Western-blot. Results The rate of MTCT was 32.1% (27/84) for children with all risk factors related to MTCT. Another 36.8% (7/19) were related to factors on intrauterine, intrapartum and breastfeeding, 35.7% (5/14) to intrapartum and breastfeeding factors, 14.3% (2/14) to intrauterine and intrapartum factors, 37.9% (11/29) to breastfeeding factor alone. By group combination analysis, the MTCT rate was 36.9% (24/65) with breastfeeding, 11.8% (2/17) with artificial feeding, and the former was significantly higher than the latter. Conclusion HIV-1 MTCT rate among mothers caused by a single blood transfusion varied with different risk factors. Breastfeeding played an important role in MTCT, appeared in our study.
