Meta-analysis on the association of G894T polymorphism in endothelial nitric oxide synthase gene and essential hypertension in Chinese population
10.3760/cma.j.issn.0254-6450.2009.08.020
- VernacularTitle:中国人内皮型一氧化氮合酶基因G894T多态性与原发性高血压关系的Meta分析
- Author:
Cong-Ju WANG
1
;
Jing-Bo ZHAO
;
Jia-Liang XU
;
Ze-Lin XIANG
;
Chang-Wei LIANG
;
Jie LI
Author Information
1. 哈尔滨医科大学
- Keywords:
Hypertension;
Endothelial nitric oxide syathase;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2009;30(8):845-849
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between G894T(Glu298Asp) polymorphism in the endothelial nitric oxide synthase (eNOS)gene and essential hypertension in Chinese population from difierent regions.Methods Odds ratios(Ors) of G894T genotype and allele distributions in essential hypertension patients against healthy controls were analyzed.All the relevant studies were screened with poor-qualified studies eliminated.Meta-analysis software MIX(Meta-analysis with interactive explanations-version 1.71),was applied for investigating and analyzing heterogeneity among individual studies and summarizing the effects across studies,and the risk of publication bias was evaluated.Results A total of 1900 cases and 1216 controls from 10 studies were included.The heterogeneity between studies Was significant(P=0.013;P=0.011) and there were substantial sources of Publication bias(P=0.049;P=0.038).The pooled OR(with 95% CI) of GT+TT vs.GG genotype was 1.79(1.33-2.42)(Z=3.83,P<0.001),and the pooled OR (with 95% CI) of T vs.G allele Was 1.73(1.32-2.27)(Z=3.92,P<0.001).Conclusion In Chinese population,mainly the Hans ethnic group,894G→T mutation in the eNOS appeared to be related to essential hypertension.
