Association between calpain-10 gene polymorphism and risk of type 2 diabetes mellitus:a Meta analysis
10.3760/cma.j.issn.0254-6450.2009.08.021
- VernacularTitle:钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析
- Author:
Ru-Yang ZHANG
1
;
Jian-Ling BAI
;
Hong-Gang YI
;
Yang ZHAO
;
Yu-Di LIN
;
Tie-Mei ZHANG
;
Feng CHEN
Author Information
1. 南京医科大学
- Keywords:
Diabetes mellitus,type 2;
Calpain-10;
Race;
Gene polymorphism;
Stratified Meta analysis
- From:
Chinese Journal of Epidemiology
2009;30(8):850-856
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to approach the relation of SNP43,SNP44 locus, main haplotypes and haplotype combinations with type 2 diabetes mellitus(T2DM).Methods According to the theory and principles of systematic review,data from case-control studies regarding the association between calpain-10(CAPN10) gene and T2DM were derived through electronic search of PubMed and Chinese journals databases.To gain a more precise estimation of the relationship,a stratified Meta-analysis with four subgroups was pertbrmed according to the races.Publication bias Was also assessed.Results The association with T2DM in different races was evaluated.In Mongoloid race,SNP43-G allele,G/G genotype and 111/221 haplotype combination showed notable association with T2DM with Ors (95%CI) as 1.368(1.155-1.620),1.437(1.186-1.741) and 2.762 (1.287-5.927) respectively.In Caucasoid race,SNP44-C allele,111/111 hapotype combination showed strong relationship with T2DM with Ors(95%CI) as 1.144(1.023-1.278),1.291(1.050-1.586) respectively.In Hybrid race,only one positive finding Was obtained which Was SNP44-C allele with OR(95%CI)as 1.653(1.025-2.665).Conclusion SNP43-G allele,G/G genotype,111/221 were risk factors to Mongoloid race.And SNP-C allele,111/111 haplotype combination were risk factors to Caucasoid race,and SNP44-C allele to Hybrid race.
