Study of the correlation between 51 immune infertility patients of the Han nationality in Anhui and HLA-DQA1 gene and treatment of Mianbu III.
- Author:
Xin BAO
1
;
Wang-jiu WANG
;
Ning DAI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; Drugs, Chinese Herbal; therapeutic use; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-DQ alpha-Chains; genetics; Humans; Infertility; drug therapy; genetics; Male; Phytotherapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2011;31(3):334-337
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between anti-sperm antibody-positive immune infertility patients and human leucocyte antigen (HLA) DQA1 gene, and to study the correlation between the treatment of Chinese medicine and pharmacy and HLA-DQA1 genotype.
METHODSThe polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used in studying HLA-DQA1 genotypes of 51 anti-sperm antibody-positive immune infertility patients and 60 healthy subjects. Mianbu III (consisting of rehmannia root, white peony root, Fructus Comi, yam, barbary wolfberry fruit, moutan bark, and dwarf lilyturf root) was used in patients for three months.
RESULTSThe HLA-DQA1 *0401 allele in the immune infertility group was obviously higher than that in the healthy control group (chi2 = 29.869, P < 0.01). As for the therapeutic efficacy 22 cases of the 27 positive HLA-DQA1 * 0401 turned to negative with statistical difference (chi2 = 5.24, P = 0.022).
CONCLUSIONHLA-DQA1 *0401 allele might be predisposing gene of the anti-sperm antibody-positive immune infertility. The Chinese medicinal treatment was effective for the HLA-DQA1 *0401 allele patients.
