Research on preparation and quality control of drug-carried poly lactic-co-glycolic acid microbubble.
- Author:
Qilin LI
1
;
Xuemo QUAN
;
Yi WANG
Author Information
1. Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
- Publication Type:Journal Article
- MeSH:
Drug Carriers;
chemistry;
Lactic Acid;
chemical synthesis;
chemistry;
Microbubbles;
Polyglycolic Acid;
chemical synthesis;
chemistry;
Quality Control
- From:
Journal of Biomedical Engineering
2010;27(5):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
This research was aimed to develop the technique and formula for the preparation of stable and effective microbubbles containing hydrophilic drugs. We prepared EB-PLGA microbubbles and evaluated its drug loading and burst release to choose the best technique and formula. The result of optimizing formula was W1/O (1:15), EB-PLGA (0.04), PVA (5%). The burst release decreased after the addition of supplemental agent and the change of method for preparation. We concluded that the optimizing formula could elevate drug loading and decrease burst release obviously.
