Degradable performance and bio-mineralization function of PLA-PEG-PLA/PLA tissue engineering scaffold in vitro and in vivo.
- Author:
Jianhua GE
1
;
Yingjun WANG
;
Shaoxiong MIN
Author Information
1. School of Material Science and Engineering, Shandong University, Ji'nan 250061, China. gjh100000@sohu.com
- Publication Type:Journal Article
- MeSH:
Animals;
Biocompatible Materials;
chemistry;
Bone Regeneration;
Bone Substitutes;
chemistry;
Implants, Experimental;
Macaca mulatta;
Polyethylene Glycols;
chemistry;
Polymers;
chemistry;
Skull;
drug effects;
physiology;
Tissue Engineering;
methods;
Tissue Scaffolds;
chemistry
- From:
Journal of Biomedical Engineering
2010;27(5):1070-1075
- CountryChina
- Language:Chinese
-
Abstract:
The degradable performance and bio-mineralization function of PLA-PEG-PLA/PLA tissue engineering scaffolds in vitro and in vivo were systematically studied. The X-ray diffraction and Fourier transform infrared spectra showed that there was the deposition of bone-like carbonate hydroxyapatite on the surface of scaffolds. We found that the weight of scaffolds did not always decrease with the prolongation of time in vitro. At the same time, we found that after the PLA-PEG-PLA/PLA tissue engineering scaffolds were embedded in skulls of rhesus monkeys, the new bone area reached 75% at the 12th week. Histological observation showed that the new bones were rebuilt and knitted bones were formed at the 12th week. These findings meant that the PLA-PEG-PLA/PLA tissue engineering scaffolds were potential in clinical use.
