Role of 6% hydroxyethylstarch 130/0.4 and furosemide in the treatment of acute pancreatitis.
- Author:
Jiandong WANG
1
;
Youdai CHEN
;
Yun DONG
;
Weijian HU
;
Ping ZHOU
;
Li CHANG
;
Shiyan FENG
;
Jian LIN
;
Yu ZHAO
Author Information
1. Emergency Medical Center, Sichuan Provincial People's Hospital, Chengdu 610072, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Child;
Child, Preschool;
Female;
Furosemide;
administration & dosage;
Humans;
Hydroxyethyl Starch Derivatives;
administration & dosage;
Hypovolemia;
prevention & control;
Infant;
Infusions, Intravenous;
Injections, Intravenous;
Male;
Middle Aged;
Pancreatitis;
drug therapy;
Young Adult
- From:
Journal of Biomedical Engineering
2010;27(5):1138-1145
- CountryChina
- Language:Chinese
-
Abstract:
This study was conducted to observe the effects of intravenously administered 6% hydroxyethylstarch 130/ 0.4 solution and furosemide on the outcome of acute pancreatitis patients. Patients admitted to our center from October 16, 2007 through August 31, 2009 were given intravenous infusions of 6% hydroxyethylstarch 130/0. 4 solution (1 000-2 000 ml administered for an adult) soon after admission. At the same time, furosemide was administered as intravenous bolus, trying to maintain a fluid balance. The dose level of hydroxyethylstarch was gradually lowered from the second day after admission. A total of 135 patients (54% of patients with a Ranson's score > or = 3 and 61% with a Balthazar CT score > or = D) were treated with our protocol. Only 4% and 7% patients developed pancreatic and systemic complications respectively; only 1 patient underwent necrosectomy. The in-hospital mortality rate was 4%. It was estimated that, on the average, 18. 3% of blood volume was lost on admission. Our study suggest that intravenously administered 6% hydroxyethylstarch 130/0. 4 solution and furosemide might be beneficial for patients with acute pancreatitis. Plasma extravasation is a central event of acute pancreatitis. The reversal of hypovolemia is crucial for the success in treatment of acute pancreatitis.
